Viral Buster & Covid Knock Out

Why IV therapy for COVID?

Malabsorption of nutrients

Covid alters the gastrointestinal track. Infection may have symptoms of nausea, vomiting, diarrhea.

Leads to dehydration, needing hydration for balance.

Osmotic changes happen to the gastrointestinal system and mucosa layer, causing sloughing or swelling due to diarrhea and immune system responses.  Oral supplementation has to compete with gut microbe’s uptake and the liver.  

You can take oral supplements, it is likely the body will flush them out with due processes. 

Resources

https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=7369504_40519_2020_963_Fig1_HTML.jpg

https://doi.org/10.1007/s40519-020-00963-y

https://doi.org/10.14309/ajg.0000000000000664

https://doi.org/10.1002/ncp.10554

doi.org/10.23937/2469-584X/1510075

Amino Acids

Covid virus needs amino acids to fuel millions and or billions of virus particles.

https://www.frontiersin.org/files/Articles/576622/fimmu-11-576622-HTML/image_m/fimmu-11-576622-g001.jpg

https://www.nature.com/articles/s41401-020-0485-4/figures/1

List of amino acids:

alanine

arginine

asparagine

aspartic acid

cysteine

glutamine

glutamic acid

glycine

histidine

isoleucine

leucine

lysine

methionine

phenylalanine

proline

serine

threonine

tryptophan

tyrosine

valine

Major Amino Acid depletion in COVID-19:

L-Glutamic acid

L-Taurine

L-Carnitine

L-Methionine

L-Asparagine

L-Phenylalanine

L-Threonine

L-Arginine

L-Glycine

L-Tryptophan

 

https://doi.org/10.1128/spectrum.00338-21

https://doi.org/10.1073/pnas.2101708118

Arginine

Covid has been using more than 6.9% of arginine in the viral spike, as well as glutamic acid and glycine.  While this depletes the body in amino acids. This in turn affects the body and the immune system as the immune system and cellular processes use the amino acids for function, maintaining enzymes, building blocks of DNA replication and body structures. Arginine and its cycle:  https://link.springer.com/article/10.1007/s00018-021-03828-4/figures/1

https://link.springer.com/article/10.1007/s00018-021-03828-4/figures/2

https://link.springer.com/article/10.1007/s00018-021-03828-4/figures/4

When Covid depletes arginine, the body’s immune system is slowed as it is also using this for building cells, WBCs and T-cells, to attack the virus. This also needs amino acids, as well as enzymes.  

https://link.springer.com/article/10.1007/s00018-021-03828-4/figures/3

This decrease in amino acids can create symptoms in the body.

Brain fog results from the amino acid decreases and inflammation. Immune system and the brain heavily rely on arginine. This arginine is in part major fuel for the virus.  Arginine is also used by blood vessels and dilation with nitric oxide. This loss leads into risks with circulation issues and in part, risk for blood clots.

https://doi.org/10.1016/j.ijid.2020.10.100

https://doi.org/10.3390/nu13113951

https://doi.org/10.3389/fimmu.2021.695972

https://doi.org/10.1007/s00018-021-03828-4

Role of Lysine

Lysine slows down Covid, helps prevent replication. Helpful in any stage, most potent in the early stages.  

Lysine can raise zinc and calcium levels and influences the immune system.

Lysine can increase cardiac output, pulmonary resistance, decrease inflammation and it can raise bradykinin levels; of which bradykinin may dilate blood vessels, reduce blood pressure and may have a cough.  

Resources

https://doi.org/10.3390/v13071301

DOI:10.4172/jaa.1000151

https://dx.doi.org/10.3390%2Fv13071301

Role of Amino Acid Blend: to replenish amino acids depleted, alleviate synthesis by bringing balance.  

 

Role of Vitamin C

Role of Vitamin C and Covid:  to reduce any oxidative stress and inflammation, influence cellular immunity and vascular integrity, augments synthesis of catecholamines and helps the immune system fight infection.

https://www.icjournal.org/ViewImage.php?Type=F&aid=695814&id=F1&afn=86_IC_52_4_461&fn=ic-52-461-g001_0086IC

https://doi.org/10.3947/ic.2020.52.4.461

Disclaimer:  Per NIH 2021: https://www.covid19treatmentguidelines.nih.gov/therapies/supplements/vitamin-c/

Recommendation for Non-Critically Ill Patients With COVID-19

There is insufficient evidence for the COVID-19 Treatment Guidelines Panel (the Panel) to recommend either for or against the use of vitamin C for the treatment of COVID-19 in non-critically ill patients.

Rationale

Because patients who are not critically ill with COVID-19 are less likely to experience oxidative stress or severe inflammation, the role of vitamin C in this setting is unknown.

NIH Clinical Trials and vitamin C

https://clinicaltrials.gov/ct2/results?cond=COVID-19&term=vitamin+c&cntry=&state=&city=&dist=

Doses of Vitamin C are variable. Some do well with low and some do well with high doses.

Glucose-6-phosphate dehydrogenase (G-6-PD) deficient patients were not good candidates to have high doses of Vitamin-C due to hemolysis.

Vitamin-C was able to improve the bioavailability of iron. A large dose of Vitamin-C was not recommended for patients with hemochromatosis.

An administration of Vitamin-C is helpful to recover mitochondrial membrane potential and gene expression of pro-inflammatory cytokines.

Systematic studies identified that the doses of Vitamin-C to volunteers or cancer patients can be up to 1.5 g/kg, (ex. a 150-200lb person up to 100-136 g of vitamin C). No toxicity risks were seen for example with glucose-6-phosphate dehydrogenase deficiency, renal diseases or urolithiasis. 

https://dx.doi.org/10.1016%2Fj.phanu.2020.100190

According to Claus Jungelbut, MD; A Further Contribution To Vitamin C Therapy In Experimental Poliomyelitis in 1939,  Lojkin in 1937, (A study of ascorbic acid as an inactivating agent of tobacco mosaic virus) studied the effects of Vitamin C- L-sodium ascorbate and found reactions that mimicked hydrogen peroxide from the redox reactions of the oxidization process in cellular plasma matrix. This hydrogen peroxide effect inhibits and destroys the virus. The studies were then considered incomplete.

https://rupress.org/jem/article-pdf/70/3/315/1181781/315.pdf

Role of N-acetylcysteine, NAC

NAC assists with detox by increasing intracellular glutathione. It also reduces inflammation and boosts the immune system by aiding lymphocytes, modulating cytokines. https://www.dovepress.com/cr_data/article_fulltext/s306000/306849/img/JIR_A_306849_O_F0001g.jpg

NAC is also used for acetaminophen overdose. Tylenol use drastically reduces your redox enzymes. Depletes NAC and glutathione as these enzymes are also depleted in infection and viral processes.

NAC also is used to prevent or diminish kidney damage via detoxification, helps relieve symptoms of respiratory conditions, and boosts brain health.

https://dx.doi.org/10.2147%2FTCRM.S273700

https://doi.org/10.2147/JIR.S306849

 

Role of NAD

NAD is suppressed and depleted in COVID as the cellular fitness balance is thrown off, It is needed for energy pathways, metabolism and it gets in a tug of war with the Covid virus in the cellular demands for ATP production.  This also leads into fatigue, brain fog and depleted reserves.  The body gets into a major fit in result and releases a ton of enzymes in interferons and cytokines to get the energy back to do its chemical work.

https://www.nature.com/articles/s42255-021-00507-3/figures/1

NAD helps to lower circulation of inflammatory cytokines and depresses expression, by doing the work load to create the enzymes needed to do the job, supply and demands.

The more we age, the less NAD we have. You want more naturally, then exercise and eat a well-balanced diet.

In Covid and infection the likelihood you want to exercise and eat and yet absorb the nutrients without getting flushed out is by chance of your healthy state.

NAD role to bring back the operational cellular balance.

Helps the brain regenerate, boosts performance and improves your memory.

Reduces symptoms of depression, boosts your mood.

Improves concentration and increases your mental clarity.

https://doi.org/10.1038/s42255-021-00507-3

https://dx.doi.org/10.1016%2Fj.mehy.2020.110044

https://doi.org/10.18632/aging.103344

https://doi.org/10.1016/j.jiph.2020.06.004

Role of Vitamins and Minerals

Minerals and Vitamins are essential players in the balance of a healthy person.  They also have roles. Repletion is central to healing in infection.

https://doi.org/10.1016/j.maturitas.2020.08.007

https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=7428453_gr1_lrg.jpg

Not into IV therapy, Huh?

If IV therapy is not your thing

Oral therapy to consider

https://doi.org/10.1177/2515690X211026193

25 mg zinc

400 mg quercetin

1000 mg vitamin C

1000 IU (25 μg) vitamin D3

400 IU Vitamin E

500 mg l-lysine

Bupleurum

NAD

NAC 600mg 

B complex